I manage Web Services for EastBay Media, a company specializing in on-demand streaming, live webcasts, 508-compliant captioning and web development. We have recently deployed two sites in Drupal after transitioning from other CMS' and are very pleased with the results. We are currently exploring ways to integrate our in-house CRM operations into Drupal, with a focus on dynamically streaming customer content through one of several CDN's, depending on criteria.